Characters: Little Mac, Glass Joe, King Hippo, Doc Louis, Von Kaiser and newcomer Disco Kid. There are a total of 13 opponents for Little Mac to step into the ring with, 12 of which are returning from previous games in the Punch-Out!! series.
Special powers/weapons/moves/features: Players can obtain special “Star Punches,” which allow Little Mac to take more Health from his rival in a single punch. Players can now use multiple stars in a single punch for an extra-powerful attack.