By 2161, it only takes a hint of unauthorized military preparation in Pacifica for the newly restored president to order a strike in the heart of Pacifican territory - an outpost in the now dry San Francisco Bay. This strike leads to the unthinkable: an epic conflict with global implications fought on U.S. soil. As a soldier in this struggle, Mason Briggs uses explosive, terrain-deforming weaponry to change the face of battle: He not only destroys the land in his path, he outright transforms it to gain the strategic advantage in completely unscripted ways no game has ever seen. With such a devastating arsenal at hand, Briggs never leaves any battlefield the way he found it.
In addition to extraordinary weaponry that allows players to do things previously only imagined, each side of the conflict, Pacifica and the Atlantic Alliance, boast soldiers with powers beyond those of ordinary men. Genetic augmentations provide Pacifican forces with amazing abilities, while Atlantic Alliance soldiers like Briggs counter the threat with the more traditional method: cybernetics. The differing states of superhumanity result in balanced yet stylistically different combat tactics that have never been seen before.